![]() This channel may be present in mitochondria ( Parrasia et al. Frag(304-613)) to form a functional channel independently of the S1-S2 linkage ( Lamothe et al. The N-terminus and S1 of Kv1.5 can attract and coassemble with the rest of the channel (i.e. Loss of function causes atrial fibrillation, a rhythm disorder characterized by chaotic electrical activity of cardiac atria ( Olson et al. This channel is regulation by sterols ( Balajthy et al. The microRNA, mmumiR449a, reduced the mRNA expression levels of transient receptor potential cation channel subfamily A member 1 (TRPA1), and calcium activated potassium channel subunit alpha1 (KCNMA1) and increased the level of transmembrane phosphatase with tension homology (TPTE) in the DRG cells ( Lu et al. During insertion of Kv1.3, the extended N-terminus of the second α-helix, S2, inside the ribosomal tunnel is converted into a helix in a transition that depends on the nascent peptide sequence at specific tunnel locations ( Tu and Deutsch 2017). Addtionally, Na vBeta1 interacts with the voltage sensing domain (VSD) of K v1.3 through W172 in the transmembrane segment to modify the gating process ( Kubota et al. Direct binding of caveolin regulates K v1 channels and allows association with lipid rafts ( Pérez-Verdaguer et al. Intracellular trafficking of the K V1.3 K + channel is regulated by the pro-domain of a matrix metalloprotease ( Nguyen et al. Interactions between the C-terminus of K v1.5 and K vβ regulate pyridine nucleotide-dependent changes in channel gating ( Tipparaju et al., 2012). ![]() The K v1.3 mitochondrial potassium channel is involved in apoptotic signalling in lymphocytes ( Gulbins et al., 2010). However, the heteromers have different biophysical and pharmacological properties. K v1.3 associates with the sequence similar (>80%) K v1.5 protein in macrophage forming heteromers that like K v1.3 homomers are r-margatoxin sensitive ( Vicente et al., 2006). Margatoxin-sensitive voltage-gated K + channel, Kv1.3 (in plasma and mitochondrial membranes of T lymphocytes) (Szabò et al., 2005).
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